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Wham clusters each of the applicant breakpoints and rounds their positions to the nearest tenth foundation pair. The position with the very best examine help is described. When the tender-clipped consensus sequence can be aligned on the putative breakpoint location using the Smith-Waterman algorithm, the breakpoint is further more refined to the lo
Wham is made for paired-conclude Illumina libraries with typical insert measurements (~300bp-500bp). Wham integrates mate-pair mapping, break up read through mapping, soft-clipping, different alignment and consensus sequence primarily based evidence to forecast SV breakpoints with solitary-nucleotide accuracy. Wham generates a combined pileup (cata